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Related Concept Videos

Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
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Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
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Related Experiment Video

Updated: Oct 8, 2025

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
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Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification

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Does the Nail Bed Regenerate?

Jefferson Braga Silva1, Gabriela A Magnus1, Valentina Stanham1

  • 1Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Hand (New York, N.Y.)
|December 29, 2021
PubMed
Summary
This summary is machine-generated.

Nail bed regeneration after trauma is possible with surgical reconstruction. The direct flow island flap technique showed superior outcomes for nail bed repair, promoting regeneration and good results in most patients.

Keywords:
digital flapfinger injuriesfingernailnail bedregeneration

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Area of Science:

  • Plastic Surgery
  • Regenerative Medicine
  • Trauma Surgery

Background:

  • The regenerative capacity of the nail bed following injury is a subject of ongoing debate.
  • Nail bed trauma can significantly impact function and aesthetics.

Purpose of the Study:

  • To evaluate the outcomes of two surgical techniques for nail bed reconstruction.
  • To determine the efficacy of direct flow island flaps and Tranquilli-Leali "Atasoy" flaps in supporting distal substance loss and promoting nail bed regeneration.

Main Methods:

  • Retrospective review of 51 patients undergoing nail bed reconstruction.
  • Comparison of direct flow island flap versus Tranquilli-Leali "Atasoy" flap outcomes.
  • Analysis of outcomes over a minimum 18-month follow-up period.

Main Results:

  • Good to excellent outcomes were achieved in 80.4% of patients.
  • The direct flow island flap demonstrated superior results across various patient demographics and injury types.
  • Nail bed regeneration was observed in cases with proper hyponychium reconstruction.

Conclusions:

  • The direct flow island flap is the preferred technique for nail bed reconstruction due to superior outcomes.
  • Successful nail bed regeneration is achievable with appropriate surgical techniques, particularly hyponychium reconstruction.