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Review of Therapies using TiO2 Nanomaterials for Increased Anticancer Capability
Noé Rodríguez-Barajas1, Luis Miguel Anaya-Esparza1,2, Zuami Villagrán-de la Mora3
1Laboratorio de Investigación en Materiales, Agua y Energía, Departamento de Ingeniería, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Mexico.
Abstract:
Recently, Titanium dioxide (TiO2) has been studied as an alternative to treat cancer diseases under different activation therapies. The aim of this review was to describe the effect of TiO2 nanoparticles (NPs) on some cancer cell lines and their interaction with phototherapies such as photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), and ultraviolet therapy (UV) for anticancer treatment. The use of TiO2 combined with PDT, PTT, SDT, or UV has shown a remarkable capacity to enhance the killing of cancer cells through reactive oxygen species formation. Thus, the combination of TiO2 and activation therapies exhibited great potential and could be a viable anticancer treatment strategy. However, more studies on phototherapies in combination with TiO2 and their effects under different experimental conditions (TiO2 concentration, type of cancer cells, and intensity and frequency of therapies) are necessary to guarantee the safe use of this kind of therapy.
Insights
Titanium dioxide nanoparticles show promise for cancer treatment when combined with therapies like photodynamic therapy. This combination enhances cancer cell killing, offering a potential new strategy for anticancer treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Titanium dioxide (TiO2) is emerging as a novel agent for cancer therapy.
- Its application is being explored across various activation-based treatment modalities.
Purpose of the Study:
- To review the effects of TiO2 nanoparticles on cancer cell lines.
- To examine the synergistic interactions between TiO2 and phototherapies for anticancer treatment.
Main Methods:
- Literature review focusing on TiO2 nanoparticles.
- Analysis of combination therapies including photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), and ultraviolet (UV) therapy.
- Evaluation of cancer cell line responses.
Main Results:
- TiO2 combined with PDT, PTT, SDT, or UV significantly enhanced cancer cell death.
- The mechanism involves the increased formation of reactive oxygen species.
- This combination therapy demonstrates a remarkable capacity for killing cancer cells.
Conclusions:
- The combination of TiO2 nanoparticles with activation therapies presents a promising strategy for anticancer treatment.
- Further research is needed to optimize parameters like TiO2 concentration and therapy conditions for safe and effective clinical application.
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