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Updated: Oct 8, 2025
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Acidic microenvironment responsive polymeric MOF-based nanoparticles induce immunogenic cell death for combined
Xiaoli Zhang1, Yi Lu2, Die Jia2
1Pediatric Research Institute, Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, 518038, Guangdong, People's Republic of China.
Background:
The complex tumor microenvironment and non-targeting drugs limit the efficacy of clinical tumor therapy. For ensuring the accurate delivery and maximal effects of anticancer drugs, it is important to develop innovative drug delivery system based on nano-strategies.
Result:
In this study, an intracellular acidity-responsive polymeric metal organic framework nanoparticle (denoted as DIMP) has been constructed, which can co-deliver the chemotherapy agent of doxorubicin (DOX) and phototherapy agent of indocyanine green (ICG) for breast carcinoma theranostics. Specifically, DIMP possesses a suitable and stable nanometer size and can respond to the acidic microenvironment in cells, thus precisely delivering drugs into target tumor sites and igniting the biological reactions towards cell apoptosis. Following in vivo and in vitro results showed that DIMP could be effectively accumulated in tumor sites and induced powerful immunogenic cell death (ICD) effect.
Conclusion:
The designed DIMP displayed its effectiveness in combined photo-chemotherapy with auxiliary of ICD effect under a multimodal imaging monitor. Thus, the present MOF-based strategy may offer a potential paradigm for designing drug-delivery system for image-guided synergistic tumor therapy.
Insights
Researchers developed a novel nanoparticle (DIMP) for targeted breast cancer therapy. This nanoparticle co-delivers chemotherapy and phototherapy agents, enhancing treatment efficacy through immunogenic cell death.
Area of Science:
- Nanotechnology
- Materials Science
- Oncology
Background:
- The tumor microenvironment and non-specific drug delivery hinder effective cancer therapy.
- Developing advanced nano-strategies is crucial for precise drug delivery and maximizing therapeutic effects.
Purpose of the Study:
- To construct an intracellular acidity-responsive polymeric metal-organic framework nanoparticle (DIMP).
- To evaluate DIMP's potential for co-delivering doxorubicin (chemotherapy) and indocyanine green (phototherapy) for breast carcinoma theranostics.
Main Methods:
- Construction of a polymeric metal-organic framework nanoparticle (DIMP).
- Assessment of DIMP's responsiveness to intracellular acidity for targeted drug release.
- In vitro and in vivo evaluation of DIMP's tumor accumulation, drug delivery, and therapeutic effects, including immunogenic cell death (ICD).
Main Results:
- DIMP nanoparticles demonstrated suitable size and stability, responding effectively to acidic tumor microenvironments.
- DIMP achieved precise drug delivery to tumor sites, initiating apoptosis via co-delivered doxorubicin and indocyanine green.
- Significant tumor accumulation and potent immunogenic cell death (ICD) effects were observed in vivo and in vitro.
Conclusions:
- The DIMP nanoparticle system is effective for combined photo-chemotherapy, augmented by ICD, under multimodal imaging guidance.
- This metal-organic framework-based strategy presents a promising approach for image-guided synergistic tumor therapy.
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