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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

245
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
245
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

375
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
375
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

262
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
262
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

350
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
350
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

170
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
170

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Related Experiment Video

Updated: Oct 8, 2025

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
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Colonic Gallstone Ileus: Treatment Challenges.

Teresa Da Cunha1, Bashar Sharma2, Steven Goldenberg2

  • 1Internal Medicine, University of Connecticut Health, Farmington, USA.

Cureus
|December 29, 2021
PubMed
Summary

Gallstone ileus in the colon is rare, especially in elderly patients, often leading to high mortality. While less invasive treatments are emerging, surgery remains the primary intervention for colonic gallstone obstruction.

Keywords:
bowel obstructioncholecystoenteric fistulacolonic gallstone ileusgallstonegallstone ileus

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Area of Science:

  • Gastroenterology
  • Surgical Gastroenterology

Background:

  • Gallstone ileus, a rare complication of cholelithiasis, typically involves the small intestine.
  • Colonic gallstone ileus is an infrequent occurrence, predominantly seen in the elderly, presenting significant management challenges and high mortality rates.

Observation:

  • A case of an 89-year-old male with sigmoid colon obstruction due to a gallstone is presented.
  • Endoscopic treatment for this colonic gallstone ileus was unsuccessful in this patient.

Findings:

  • Gallstone obstruction at the colonic level is an uncommon condition.
  • Elderly patients with colonic gallstone ileus face high mortality due to complex treatment.
  • Surgical intervention remains the definitive treatment for colonic gallstone ileus, despite evolving less invasive options.

Implications:

  • This case highlights the challenges in managing colonic gallstone ileus, particularly when less invasive methods fail.
  • A comprehensive literature review was conducted to analyze presentation, diagnostics, and treatment of colonic gallstone ileus.
  • Further research may refine treatment strategies for this rare but serious condition.