Strategies for sustained drug release from electrospun multi-layer nanostructures

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery Systems

Background:

• Sustained drug release (SDR) is crucial for safe, effective, and convenient drug delivery.
• Electrospun nanofibers have emerged as a popular platform for SDR applications.
• Advances in electrospinning techniques allow for complex multi-chamber nanostructures.

Purpose of the Study:

• To review the historical development of electrospinning for SDR.
• To summarize current multi-chamber core-shell nanostructures.
• To categorize and exemplify strategies for achieving SDR profiles using electrospun nanomaterials.

Main Methods:

• Literature review of electrospinning techniques and SDR applications.
• Analysis of multi-chamber nanostructure fabrication.
• Categorization of 15 distinct strategies for SDR.

Main Results:

• Electrospinning has evolved from simple blending to complex multi-fluid processes, enabling sophisticated nanostructures.
• Multi-chamber nanostructures provide a versatile platform for novel SDR strategies.
• Fifteen distinct strategies for achieving SDR profiles have been identified and exemplified.

Conclusions:

• Electrospun multi-chamber nanostructures represent a powerful emerging technology for advanced drug delivery.
• Further development in this area holds significant promise for promoting SDR.
• This review provides a comprehensive overview and future perspectives on electrospun nanomaterials for SDR.