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The emerging roles of the CDK/cyclin complexes in antiviral innate immunity

Chunfu Zheng1,2, Yan-Dong Tang3

  • 1Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Journal of Medical Virology
|December 29, 2021
PubMed

Insights

Cyclin-dependent kinases (CDKs) are crucial for cell cycle control and emerging roles in antiviral innate immunity. This review highlights CDK involvement in immune responses against viruses.

Area of Science:

  • Molecular Biology
  • Immunology
  • Cell Biology

Background:

  • Human cyclin-dependent kinases (CDKs) are a family of over 20 proteins activated by cyclins.
  • CDKs regulate critical cellular processes including cell cycle, transcription, DNA damage response, and apoptosis.
  • Dysregulation of CDKs is implicated in diseases such as cancer.

Purpose of the Study:

  • To summarize the emerging roles of CDKs in antiviral innate immunity.
  • To highlight the involvement of CDKs, individually or in CDK/cyclin complexes, in antiviral responses.
  • To draw attention to this under-explored area of CDK function.

Main Methods:

  • This minireview synthesizes existing scientific literature.
  • It focuses on studies investigating CDK involvement in antiviral innate immunity.

Main Results:

  • CDKs are essential regulators of the cell cycle.
  • Evidence is accumulating on the significant roles of CDKs in antiviral innate immunity.
  • Both individual CDKs and CDK/cyclin complexes are involved in these immune processes.

Conclusions:

  • CDKs play a critical, though often overlooked, role in antiviral innate immunity.
  • Further research into CDK functions in immunity is warranted.
  • Understanding CDK involvement may offer new therapeutic avenues for viral infections.
Keywords:
CDKsJAK-STATNF-κBTLRantiviral innate immunity

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