Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long-term depressed immune function in patients splenectomized for trauma.

E C Downey, S R Shackford, P H Fridlund

    The Journal of Trauma
    |June 1, 1987
    PubMed
    Summary

    Adults without spleens (asplenic) show lasting immune system changes, including lower B-cell counts and T-cell responses. These immune deficits may explain their higher risk of sepsis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prostaglandins and immunity.

    Immunology today·2014
    Same author

    Prostaglandins in inflammation and disease.

    Immunology today·2014
    Same author

    "How then shall we live?".

    The Journal of trauma·2001
    Same author

    Fetus in fetu: a rare cause of a neonatal mass.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2001
    Same author

    Chest radiographs of limited utility in the diagnosis of blunt traumatic aortic laceration.

    The Journal of trauma·2001
    Same author

    A population-based study of geriatric trauma in a rural state.

    The Journal of trauma·2001

    Area of Science:

    • Immunology
    • Hematology
    • Trauma Surgery

    Background:

    • Splenectomy, the surgical removal of the spleen, can lead to long-term health consequences.
    • Asplenic individuals are known to have an increased risk of severe infections, particularly sepsis.
    • Understanding the immunological impact of splenectomy is crucial for managing asplenic patients.

    Purpose of the Study:

    • To investigate the persistent immunological alterations in adult trauma patients following splenectomy.
    • To compare immune cell populations and function between asplenic and healthy individuals.
    • To identify potential immunological factors contributing to the increased septic risk in asplenic patients.

    Main Methods:

    • Analysis of peripheral blood from asplenic trauma patients (ASP) and normal controls (C).

    Related Experiment Videos

  • Quantification of immunoglobulin and complement levels.
  • Assessment of T- and B-lymphocyte populations and T-cell mitogen response (PHA).

    • Main Results:

    • Asplenic patients exhibited significantly higher total lymphocyte, T-cell, and B-cell counts compared to controls.
    • T-cell response to phytohemagglutinin (PHA) was significantly diminished in asplenic patients at 3 and 5 days.
    • Reduced levels of Immunoglobulin M (IgM) were observed in asplenic patients, while complement levels (C3, C4, C5) remained similar.

    Conclusions:

    • Adult asplenic patients demonstrate persistent abnormalities in immune function years after splenectomy.
    • These immune dysfunctions include altered lymphocyte counts and impaired T-cell responsiveness.
    • The findings suggest a potential immunological basis for the heightened susceptibility to sepsis in asplenic individuals.