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Assessing Activity-based Anorexia in Mice
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Anhedonia in Eating Disorders.

Susan M Murray1, Carina S Brown1, Walter H Kaye1

  • 1Department of Psychiatry, University of California San Diego, UCSD Eating Disorders Center for Treatment and Research, San Diego, CA, USA.

Current Topics in Behavioral Neurosciences
|December 29, 2021
PubMed
Summary

Anhedonia, the inability to feel pleasure, is common in eating disorders (ED). This review explores its role in anorexia nervosa (AN) and bulimia nervosa (BN) by examining reward processing mechanisms.

Keywords:
AnhedoniaAnorexia nervosaBulimia nervosaEating disordersReward

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Eating Disorder Research

Background:

  • Anhedonia is prevalent in individuals with eating disorders (ED), but its specific role in ED pathology and clinical outcomes is not well understood.
  • Existing research primarily focuses on anorexia nervosa (AN) and bulimia nervosa (BN).

Purpose of the Study:

  • To present current findings on anhedonia in ED, focusing on AN and BN.
  • To examine anhedonia through the lens of altered reward processing, including subjective experiences, neurochemistry, neural correlates, and cognitive functions related to reward components (liking, wanting, learning).

Main Methods:

  • Review of the latest scientific literature on anhedonia in ED.
  • Analysis of data related to subjective experience, neurotransmitter function, neural correlates, and cognitive performance in reward processing.
  • Inclusion of findings from animal models.

Main Results:

  • Anhedonia is linked to altered reward processing in ED, impacting distinct components of reward.
  • Evidence from human studies and animal models suggests specific neurobiological and cognitive underpinnings.
  • The chapter synthesizes current knowledge on the multifaceted nature of anhedonia in AN and BN.

Conclusions:

  • Anhedonia significantly impacts the understanding and treatment of eating disorders.
  • Further research is needed to elucidate the precise mechanisms and develop targeted therapeutic interventions.
  • Understanding anhedonia's role in reward processing is crucial for improving clinical outcomes in ED patients.