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Updated: Oct 8, 2025
07:29
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
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[Ocular iontophoresis].
A K Drakon1, L S Pateyuk1, V M Sheludchenko1
1Research Institute of Eye Diseases, Moscow, Russia.
Vestnik Oftalmologii
|December 29, 2021
Summary
Iontophoresis uses electric current to deliver medication through the skin for therapeutic benefits. This method shows clinical effectiveness in ophthalmology, offering a novel drug delivery system.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Physical Medicine
Background:
- Iontophoresis combines electrical stimulation with drug delivery.
- Understanding the physical and chemical mechanisms is key to its application.
- Its use in ophthalmology is an area of growing research.
Purpose of the Study:
- To explain the physical principles of iontophoresis.
- To detail the mechanisms of drug administration via electric current.
- To review clinical evidence for iontophoresis in ophthalmology.
Main Methods:
- Review of physical principles of direct electric current on tissues.
- Analysis of physicochemical mechanisms for transdermal drug delivery.
- Synthesis of findings from international and domestic studies on clinical efficacy.
Main Results:
- Direct electric current has a defined physical effect on biological tissues.
- Specific physical and chemical processes facilitate targeted drug delivery through intact skin/mucous membranes.
- Clinical studies demonstrate the effectiveness of iontophoresis in ophthalmological treatments.
Conclusions:
- Iontophoresis is a viable method for transdermal drug delivery.
- The underlying physical and chemical mechanisms are well-defined.
- Evidence supports its clinical application in ophthalmology.
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