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Advances in Approaches to Study Chromatin-Mediated Epigenetic Memory
Yuan Yao1, Qing Wen1, Tianjun Zhang1,2
1Shenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
ACS Synthetic Biology
|December 29, 2021
Summary
Parental histone recycling is crucial for epigenetic inheritance, ensuring daughter cells maintain gene expression. New synthetic biology tools help analyze epigenetic components in fungi and mammals.
Area of Science:
- Epigenetics and molecular biology
- Chromatin biology and inheritance
Background:
- Histone post-translational modifications (PTMs) carry epigenetic information.
- Parental histone recycling by replisome proteins is vital for epigenetic inheritance.
- Maintaining gene expression patterns across cell divisions relies on epigenetic memory.
Purpose of the Study:
- Review mechanisms of epigenetic modification establishment and maintenance in fungi.
- Discuss parental histone chaperones and their role in transcriptional silencing inheritance.
- Summarize synthetic biology approaches for analyzing epigenetic inheritance.
Main Methods:
- Review of fungal epigenetic models.
- Discussion of histone chaperone functions.
- Summary of synthetic biology tools for epigenetic analysis.
Main Results:
- Fungal models elucidate fundamental epigenetic establishment and maintenance.
- Parental histone recycling impacts heterochromatin-mediated silencing inheritance.
- Synthetic biology enables bottom-up dissection of epigenetic systems.
Conclusions:
- Parental histone recycling is essential for epigenetic inheritance.
- Synthetic biology offers powerful approaches to study and engineer epigenetic systems.
- Engineered regulators have potential applications in building synthetic epigenetic systems.
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