Related Experiment Video
Updated: Oct 8, 2025
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
Visual function correlates with foveal slope, retinal and choroidal thickness on optical coherence tomography in type
Ramesh Venkatesh1, Sameeksha Agrawal1, Nikitha Gurram Reddy1
1Department of Retina and Vitreous Narayana Nethralaya, Bengaluru India.
Purpose:
To correlate the foveal slope angle (FSA), retinal (RT) and choroidal (CT) thickness measured using optical coherence tomography (OCT) across different stages of type 2 macular telangiectasia (MacTel) with best-corrected visual acuity (BCVA).
Methods:
A cross-sectional study of 182 gradable quality macular OCT images of 49 patients with type 2 MacTel was carried out. RT was measured on the Spectralis OCT machine from ETDRS (Early Treatment Diabetic Retinopathy Study) retinal thickness map and later used for calculating FSA. RT and CT were measured at 500-µm intervals up to 1500 µm from foveal centre manually. The change in RT, CT and FSA across five stages of type 2 MacTel was assessed. The measurements were correlated with BCVA.
Results:
The FSA, RT and CT were calculated quadrantwise and stagewise. The FSA and RT showed a significant negative correlation with disease stage and BCVA (p < .05) in all four quadrants. No significant correlation was noted between CT and BCVA. Multivariate linear regression analysis identified the temporal FSA to correlate best with BCVA.
Conclusion:
BCVA correlates best with temporal FSA. Smaller the temporal FSA, poorer the vision.
