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Updated: Oct 8, 2025

Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
A new anti-proliferative compound from an endophytic fungus, Phoma sp
Hyeri Ku1, Ji-Yun Baek2, Ki Sung Kang2
1Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Abstract:
A new oxazole-type compound (1), named macrooxazole E, and three known macrooxazoles A-C (2-4), were isolated from ethyl acetate (EtOAc) extracts of Phoma sp. JS0228 cultures, an endophytic fungus of Morus alba (M. alba). Structures of the isolated compounds were determined using spectroscopic methods, such as 1 D- and 2 D-nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS). Macrooxazole E (1) differed from macrooxazole C only in the presence of methyl carboxylate instead of free carboxylic acid. Macrooxazole C showed moderate anti-proliferative activities against human breast cancer (MCF-7) and prostate cancer (LNCaP) cell lines with IC50 values of 0.29 mM and 0.36 mM, respectively. This study presents the possibility of the endophytic fungus Phoma sp. JS0228 to produce new bioactive natural compounds.
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Bacterial Phylum Planctomycetes
Fungal Group Zygomycota

