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Updated: Oct 8, 2025
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Murine Renal Transplantation Procedure
Published on: July 10, 2009
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Waiting Time for Second Kidney Transplantation and Mortality
Alexander Kainz1, Michael Kammer1,2, Roman Reindl-Schwaighofer1
1Department of Nephrology, Medical University of Vienna, Vienna, Austria.
Clinical Journal of the American Society of Nephrology : CJASN
|December 30, 2021
Summary
Second kidney transplantation improves survival compared to dialysis, but this benefit decreases with longer wait times after the first graft fails. This is crucial information for patients awaiting a second kidney transplant.
Area of Science:
- Nephrology
- Transplantation Immunology
- Clinical Epidemiology
Background:
- Kidney transplant half-life averages 10-15 years.
- Donor organ scarcity and sensitization impact retransplantation.
- Need for data on second transplant survival versus dialysis.
Purpose of the Study:
- Investigate patient survival for second kidney transplant versus remaining on the waitlist.
- Analyze the association between waiting time and survival outcomes.
Main Methods:
- Retrospective study using target trial emulation.
- Data from 2346 patients in the Austrian Dialysis and Transplant Registry and Eurotransplant (1980-2019).
- Comparison of retransplantation versus remaining on dialysis for patients with a failed first graft.
Main Results:
- Second kidney transplant showed longer restricted mean survival time (5.8 months gained at 10 years).
- Survival benefit diminished with longer waiting times for retransplantation.
- Minimal survival difference (0.1 months gained) at 8 years waiting time.
Conclusions:
- Second kidney transplant is linked to improved patient survival versus dialysis.
- The survival advantage of retransplantation decreases as waiting time increases.
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