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G-Protein Coupled Receptor Signaling and Mammalian Target of Rapamycin Complex 1 Regulation
Chase H Melick1, Tshering D Lama-Sherpa1, Adna Curukovic1
1Department of Molecular Biology, Harold C. Simmons Comprehensive Cancer, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Molecular Pharmacology
|December 30, 2021
Summary
The mammalian target of rapamycin complex 1 (mTORC1) regulates cell functions and is a key target in diseases. This review details how G-protein coupled receptor signaling influences mTORC1 activity.
Area of Science:
- Cellular Biology
- Molecular Biology
- Biochemistry
Background:
- The mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolism, growth, and autophagy.
- Hyperactivation of mTOR complex 1 (mTORC1) is implicated in various human diseases, making it a significant therapeutic target.
- Identifying upstream regulators of mTORC1 is crucial for developing effective therapeutic strategies.
Purpose of the Study:
- To review the upstream regulation of mTORC1 by various stimuli.
- To specifically elucidate the role of G-protein coupled receptor (GPCR) signaling in mTORC1 regulation.
- To provide insights into targeting hyperactivated mTORC1 in disease contexts.
Main Methods:
- This mini-review synthesizes existing literature on mTORC1 regulation.
- Focuses on signaling pathways originating from G-protein coupled receptors.
- Examines molecular mechanisms linking GPCRs to mTORC1 activation.
Main Results:
- GPCRs represent a significant class of upstream stimuli that modulate mTORC1 activity.
- Specific signaling cascades downstream of GPCRs converge to regulate mTORC1.
- Understanding these pathways offers potential therapeutic avenues.
Conclusions:
- GPCR signaling plays a critical role in controlling mTORC1 activity.
- Elucidating these molecular connections is vital for understanding disease pathogenesis.
- Targeting GPCR-mTORC1 interactions may offer novel therapeutic strategies for diseases associated with mTORC1 hyperactivation.
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