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Considerations for Peripheral Blood Stem Cell Apheresis in a Low Body Weight Infant
Suvir Singh1, Shruti Kakkar2, Karambir Singh3
1Departments of Clinical Hematology and Stem Cell Transplantation.
Introduction:
Peripheral blood stem cell (PBSC) apheresis in infants (<10 kg body weight) requires specific precautions to prevent periprocedural complications.
Case Report:
A 9 month old child was diagnosed with high-risk neuroblastoma and planned for autologous stem cell transplantation after induction chemotherapy. We illustrate the precautions and technical details observed while performing PBSC collection in this patient.
Discussion:
Use of continuous flow devices, priming of apheresis circuits, appropriate flow rates and continuous monitoring can help to mitigate several procedure related complications.
Conclusions:
PBSC apheresis in infants (<10 Kg) is safe and feasible with appropriate precautions detailed above.
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