Positive end-expiratory pressure individualization guided by continuous end-expiratory lung volume monitoring during...

To determine whether end-expiratory lung volume measured with volumetric capnography (EELV_CO2) can individualize positive end-expiratory pressure (PEEP) setting during laparoscopic surgery. We studied patients undergoing laparoscopic surgery subjected to Fowler (F-group; n = 20) or Trendelenburg (T-group; n = 20) positions. EELV_CO2 was measured at 0° supine (baseline), during capnoperitoneum (CP) at 0° supine, during CP with Fowler (head up + 20°) or Trendelenburg (head down - 30°) positions and after CP back to 0° supine. PEEP was adjusted to preserve baseline EELV_CO2 during and after CP. Baseline EELV_CO2 was statistically similar to predicted FRC in both groups. At supine and CP, EELV_CO2 decreased from baseline values in F-group [median and IQR 2079 (768) to 1545 (725) mL; p = 0.0001] and in T-group [2164 (789) to 1870 (940) mL; p = 0.0001]. Change in body position maintained EELV_CO2 unchanged in both groups. PEEP adjustments from 5.6 (1.1) to 10.0 (2.5) cmH₂O in the F-group (p = 0.0001) and from 5.6 (0.9) to 10.0 (2.6) cmH₂O in T-group (p = 0.0001) were necessary to reach baseline EELV_CO2 values. EELV_CO2 increased close to baseline with PEEP in the F-group [1984 (600) mL; p = 0.073] and in the T-group [2175 (703) mL; p = 0.167]. After capnoperitoneum and back to 0° supine, PEEP needed to maintain EELV_CO2 was similar to baseline PEEP in F-group [5.9 (1.8) cmH₂O; p = 0.179] but slightly higher in the T-group [6.5 (2.2) cmH₂O; p = 0.006]. Those new PEEP values gave EELV_CO2 similar to baseline in the F-group [2039 (980) mL; p = 0.370] and in the T-group [2150 (715) mL; p = 0.881]. Breath-by-breath noninvasive EELV_CO2 detected changes in lung volume induced by capnoperitoneum and body position and was useful to individualize the level of PEEP during laparoscopy.Trial registry: Clinicaltrials.gov NCT03693352. Protocol started 1st October 2018.