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Updated: Oct 8, 2025

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
Published on: February 20, 2017
Relationship between enlarged cardiac silhouette on chest X-ray and left ventricular size on transthoracic
Soohyun A Chang1, Jeffrey Yim2, Darwin F Yeung2
1Division of Cardiology, University of British Columbia, 2775 Laurel Street, Vancouver, V5Z 1M9, Canada. s.chang@alumni.ubc.ca.
Insights
The cardiothoracic ratio on chest X-ray does not accurately predict left ventricular enlargement. Echocardiography measurements showed no significant correlation, indicating the ratio is unreliable for diagnosing this condition.
Area of Science:
- Cardiology
- Radiology
- Diagnostic Imaging
Background:
- The cardiothoracic ratio (CTR) on chest X-ray is traditionally associated with cardiomegaly.
- Its diagnostic accuracy for detecting left ventricular (LV) enlargement remains poorly defined.
- Accurate assessment of LV size is crucial for cardiovascular health management.
Purpose of the Study:
- To evaluate the predictive accuracy of the CTR for LV enlargement.
- To compare CTR with indexed linear measurements of the LV obtained via transthoracic echocardiography (TTE).
Main Methods:
- Retrospective analysis of 173 patients who underwent both chest X-ray and TTE within 90 days.
- LV end-diastolic dimension (LVEDD) and indexed LVEDDI were measured using TTE.
- CTR was calculated from posteroanterior chest X-rays.
Main Results:
- No significant correlation was found between CTR and LVEDD (r=0.011, p=0.879) or LVEDDI (r=0.122, p=0.111).
- The CTR's ability to predict LV enlargement (LVEDDI > 30 mm/m²) was not statistically significant.
- Mean CTR was 0.56 ± 0.09; mean LVEDDI was 27 ± 4.5 mm/m².
Conclusions:
- The cardiothoracic ratio on chest X-ray is not a reliable predictor of left ventricular enlargement.
- TTE provides more accurate indexed linear measurements for assessing LV size.
- Relying on CTR alone for diagnosing LV enlargement may lead to misdiagnosis.
Abstract:
The diagnostic accuracy of the cardiothoracic ratio on chest X-ray to detect left ventricular (LV) enlargement has not been well defined despite its traditional association with cardiomegaly. We aimed to determine whether the cardiothoracic ratio can accurately predict LV enlargement based on indexed linear measurements of the LV on transthoracic echocardiography (TTE). We included consecutive patients who had a TTE and a posteroanterior chest X-ray performed within 90 days of each other at a tertiary care center. LV size was determined by measuring the LV end-diastolic dimension (LVEDD) and LV end-diastolic dimension indexed (LVEDDI) to body surface area. The cardiothoracic ratio was calculated by dividing the maximum transverse diameter of the cardiac silhouette by the maximum transverse diameter of the right and left lung boundaries. 173 patients were included in the study (mean age 68 ± 15 years, 49.1% female). Mean cardiothoracic ratio was 0.56 ± 0.09, and the mean LVEDD and indexed LVEDDI were of 47 ± 8.6 mm and dimension of 27 ± 4.5 mm/m2 respectively. There was no significant correlation between the cardiothoracic ratio measured on chest X-ray and either the LVEDD or LVEDDI measured on TTE (r = 0.011, p = 0.879; r = 0.122, p = 0.111). The ability of the cardiothoracic ratio to predict LV enlargement (defined as LVEDDI > 30 mm/m2) was not statistically significant. The cardiothoracic ratio on chest X-ray is not a predictor of LV enlargement based on indexed linear measurements of the LV by TTE.
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