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Published on: April 19, 2024

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Cardiovascular and haematological events post COVID-19 vaccination: A systematic review

Dana Al-Ali1, Abdallah Elshafeey1, Malik Mushannen1

  • 1Weill Cornell Medicine Qatar, Doha, Qatar.

Journal of Cellular and Molecular Medicine
|December 30, 2021
PubMed

Insights

This review examines rare cardiovascular and hematological side effects following COVID-19 vaccination. Understanding these events is crucial for addressing vaccine hesitancy and ensuring global public health.

Area of Science:

  • Immunology
  • Cardiology
  • Hematology

Background:

  • The global COVID-19 pandemic caused significant morbidity and mortality.
  • Extensive efforts have focused on developing SARS-CoV-2 vaccines.
  • Concerns regarding vaccine safety and reported side effects have led to vaccine hesitancy.

Purpose of the Study:

  • To compile reported cardiovascular and hematological events after COVID-19 vaccination from published literature.
  • To propose potential mechanisms underlying these rare post-vaccination phenomena.

Main Methods:

  • Systematic literature review of published studies.
  • Analysis of reported cardiovascular and hematological adverse events post-vaccination.
  • Synthesis of proposed etiological mechanisms.

Main Results:

  • Identified and categorized various cardiovascular events (e.g., myocarditis, thrombosis).
  • Documented hematological events (e.g., thrombocytopenia) associated with vaccination.
  • Summarized proposed biological pathways linking vaccines to these events.

Conclusions:

  • COVID-19 vaccination is associated with rare cardiovascular and hematological events.
  • Further research into underlying mechanisms is needed to address safety concerns.
  • Evidence-based information can help mitigate vaccine hesitancy and support public health initiatives.

Keywords:
COVID-19haemorrhagemyocardial infractionmyocarditismyopericarditispericarditisthrombocytopeniathrombosisvaccine

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