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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Hydrogels for Modified-release Drug Delivery Systems.

Aleksandra Zielińska¹, Piotr Eder², Lucas Rannier³

¹Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.

Current Pharmaceutical Design

|December 30, 2021

Summary

Hydrogels are advanced polymer networks revolutionizing drug delivery. This review highlights their use in modified-release systems, improving drug efficacy and patient safety across various administration routes.

Keywords:

HMDDS Hydrogels bioavailability drug delivery modified-release safety

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Area of Science:

Polymer Science
Materials Science
Pharmaceutical Sciences

Background:

Hydrogels are increasingly important in the pharmaceutical industry for modified-release drug delivery systems.
The global market for polymers in drug delivery is projected to reach $31.4 million by 2027.
This review focuses on recent advancements and future prospects of hydrogels in drug delivery.

Purpose of the Study:

To review recent advances in hydrogel applications for drug delivery.
To discuss the perspectives of hydrogel-based drug delivery systems.
To identify key polymer characteristics for ideal hydrogel formulations across different administration routes.

Main Methods:

A comprehensive literature search was conducted in January 2021.
Studies published between January 2010 and December 2020 were included.
The review describes polymer characteristics and formulation strategies for hydrogel drug delivery.

Main Results:

Hydrogels offer significant advantages for modified-release drug delivery.
They are effective for oral, parenteral, nasal, topical, and ophthalmic delivery routes.
Key polymer properties for specific administration routes were detailed.

Conclusions:

Hydrogels enhance drug bioavailability and patient compliance.
They reduce dosing frequency and associated side effects.
Hydrogels improve the overall safety and efficacy of pharmaceutical treatments.