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Changes in Choroidal Vascularity Index (CVI) in Intermediate Uveitis.

Wijak Kongwattananon1,2, Aman Kumar2,3, Enny Oyeniran1

  • 1National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.

Translational Vision Science & Technology
|December 30, 2021
PubMed
Summary

Choroidal vascularity index (CVI) increases as active intermediate uveitis resolves, but remains stable in quiescent intermediate uveitis. This suggests CVI can monitor treatment response in uveitis.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Vascular Biology

Background:

  • Intermediate uveitis is an inflammatory condition affecting the eye.
  • Choroidal vascularity changes may be involved in intermediate uveitis.
  • Enhanced depth imaging optical coherence tomography (EDI-OCT) allows visualization of the choroid.

Purpose of the Study:

  • To investigate longitudinal changes in choroidal vascularity index (CVI) in intermediate uveitis.
  • To compare CVI in active versus quiescent intermediate uveitis.
  • To assess CVI as a potential noninvasive marker for treatment response.

Main Methods:

  • Retrospective review of EDI-OCT images from patients with intermediate uveitis.
  • Binarization of OCT images using ImageJ software to calculate CVI.
  • Measurement and comparison of choroidal parameters (CVI, TCA, LA, SA, SCT) at baseline and follow-up.

Main Results:

  • Eyes with active intermediate uveitis showed a significant increase in CVI upon resolution of inflammation (P < 0.001).
  • Eyes with quiescent intermediate uveitis exhibited no significant change in CVI during follow-up (P = 0.850).
  • Thirty-eight eyes with active and 30 eyes with quiescent intermediate uveitis were analyzed.

Conclusions:

  • Choroidal vascularity index (CVI) significantly increases with the resolution of active inflammation in intermediate uveitis.
  • CVI remains stable in quiescent intermediate uveitis, indicating its potential as a noninvasive tool for monitoring treatment response.
  • Findings suggest choroidal vasculature involvement in uveitis, even without clinical signs of choroiditis.