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Related Experiment Video

Updated: Oct 8, 2025

Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Driving DNA Origami Assembly with a Terahertz Wave.

Chao Zhang1, Yifang Yuan2,3, Kaijie Wu2,4

  • 1Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.

Nano Letters
|December 30, 2021
PubMed
Summary

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This summary is machine-generated.

Terahertz (THz) waves can unwind DNA structures by resonating with DNA bases, enabling efficient DNA origami assembly. This discovery offers new insights into THz wave bioeffects and biomolecular interactions.

Area of Science:

  • Biophysics
  • Molecular Biology
  • Nanotechnology

Background:

  • Terahertz (THz) waves exhibit complex interactions with biological systems, but molecular mechanisms remain unclear.
  • Understanding these interactions is crucial for developing novel bio-applications of THz technology.

Purpose of the Study:

  • To investigate the molecular mechanisms of THz wave interactions with DNA structures.
  • To explore the potential of THz waves for DNA origami assembly.

Main Methods:

  • Utilizing DNA origami as a model system to study THz wave effects.
  • Applying 35.2 THz illumination and computational modeling to analyze DNA unwinding.
  • Comparing THz-driven assembly with conventional contact heating.

Main Results:

Keywords:
DNA origamiin situ assemblynear-physiological environmentsnonthermal effectterahertz illumination

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  • THz illumination (35.2 THz) induced DNA duplex unwinding at 10 °C below melting point.
  • Computational analysis revealed THz resonance with DNA base vibrations, leading to hydrogen bond breaking.
  • THz illumination significantly enhanced DNA origami assembly yield (>80%) compared to contact heating.
  • Demonstrated in situ DNA origami assembly in cell lysate.

Conclusions:

  • THz waves can controllably manipulate DNA structures through combined thermal and nonthermal effects.
  • This method offers a novel, efficient approach for DNA origami assembly with potential for in situ applications.
  • Provides new insights into the bioeffects of THz waves on biomacromolecules.