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Self-Cascade Uricase/Catalase Mimics Alleviate Acute Gout
Anqi Lin1,2, Ziying Sun1, Xingquan Xu1
1State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, People's Republic of China.
Nano Letters
|December 30, 2021
Summary
A novel Pt/CeO2 nanozyme efficiently degrades uric acid and eliminates harmful hydrogen peroxide, offering a promising enzyme-mimetic treatment for gout by reducing inflammation and pain.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Rheumatology
Background:
- Gout treatment is limited by uric acid buildup and hydrogen peroxide accumulation.
- Existing therapies struggle with slow metabolism in arthritic environments.
- Complex nanozyme composites have been used to address these limitations.
Purpose of the Study:
- To develop a self-cascade nanozyme for simultaneous uric acid degradation and hydrogen peroxide elimination.
- To investigate the uricase- and catalase-like activities of platinum-group metals, specifically Pt/CeO2.
- To evaluate the therapeutic efficacy of Pt/CeO2 in a gout rat model.
Main Methods:
- Synthesized Pt/CeO2 nanozyme with optimized platinum and cerium dioxide ratio.
- Assessed uric acid degradation and hydrogen peroxide elimination capabilities.
- Evaluated reactive oxygen and nitrogen species scavenging activities.
- Tested the nanozyme in a monosodium urate-induced acute gout rat model.
Main Results:
- Optimized Pt/CeO2 (1/5) demonstrated high efficiency in degrading uric acid and eliminating H2O2.
- The nanozyme exhibited excellent scavenging of reactive oxygen and nitrogen species.
- In gout rats, Pt/CeO2 significantly reduced pain, joint swelling, and inflammation.
- Improved gait and tissue health were observed in treated rats.
Conclusions:
- Pt/CeO2 nanozyme offers a dual-action, enzyme-mimetic approach for gout treatment.
- This nanozyme effectively addresses limitations of traditional uricase-based therapies.
- The findings present a novel strategy for efficient gout management.
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