Targeting regulated cell death in aortic aneurysm and dissection therapy

Area of Science:

• Cell Biology
• Pathology
• Cardiovascular Research

Background:

• Regulated cell death (RCD) is crucial for tissue homeostasis.
• Novel RCD types, including ferroptosis and pyroptosis, have been recently defined.
• The pathogenesis of aortic aneurysm and dissection (AAD) remains incompletely understood.

Purpose of the Study:

• To review the roles of various regulated cell death types in AAD.
• To provide a framework for understanding RCD's involvement in AAD.
• To highlight potential therapeutic strategies targeting RCD in AAD.

Main Methods:

• Literature review of studies on RCD and AAD.
• Analysis of existing research on cell death mechanisms in AAD pathogenesis.
• Synthesis of information on in vitro and in vivo interventions for AAD.

Main Results:

• Cell death of smooth muscle cells, endothelial cells, and inflammatory cells contributes to AAD development.
• Interventions targeting cell death pathways show promise in alleviating AAD progression.
• Various RCD types are implicated in the molecular mechanisms of AAD.

Conclusions:

• Regulated cell death is a significant factor in AAD pathogenesis.
• Targeting specific RCD pathways presents a promising therapeutic avenue for AAD.
• Further research into RCD mechanisms can elucidate AAD's molecular underpinnings.