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Updated: Oct 8, 2025

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
Published on: January 31, 2025
Spectrogram decomposition of ultrasonic guided waves for cortical thickness assessment using basis learning.
Meilin Gu1, Yifang Li2, Tho N H T Tran3
1Center for Biomedical Engineering, Fudan University, Shanghai 200433, China.
A new spectrogram decomposition technique accurately separates overlapping ultrasonic guided waves (UGWs) modes, even in low signal conditions. This advancement enables precise bone characterization and cortical thickness estimation using UGWs.
Area of Science:
- Biomedical Engineering
- Materials Science
- Acoustics
Background:
- Ultrasonic guided waves (UGWs) are valuable for bone characterization but are complicated by multimode and dispersive wave packets.
- Existing single-channel mode separation algorithms struggle with significantly overlapping modes in the time-frequency domain, limiting accuracy.
- Accurate separation of individual UGW modes and their dispersion curves is crucial for reliable bone property assessment.
Purpose of the Study:
- To develop an automated method for separating individual ultrasonic guided wave modes under severe overlapping and low signal-to-noise ratio (SNR) conditions.
- To utilize the extracted modes for accurate estimation of cortical bone thickness.
- To validate the proposed technique using both simulated and experimental bone data.
Main Methods:
- A spectrogram decomposition technique combining generalized separable nonnegative matrix factorization (GS-NMF) and adaptive basis learning was developed.
- The method focuses on automatic mode extraction from complex UGW signals.
- Extracted modes were employed for cortical thickness estimation.
Main Results:
- The proposed technique successfully separated multimodal UGWs even with severe overlapping and low SNR.
- Simulated data showed low relative errors (0.88%-1.43%) between extracted and theoretical dispersion curves.
- Cortical thickness estimation yielded low root-mean-square errors (0.039-0.052 mm) for bone samples.
Conclusions:
- The developed spectrogram decomposition technique effectively overcomes limitations of previous methods for UGW mode separation.
- The approach enables accurate bone characterization and cortical thickness assessment in challenging signal conditions.
- This advancement holds significant potential for non-destructive evaluation and medical diagnostics using UGWs.
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