Related Experiment Video
Updated: Oct 8, 2025
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
Congenital herpes simplex virus infection among hospitalized infants in Poland
Michał Rząd1, Aneta Nitsch-Osuch1, Piotr Zbigniew Tyszko2
1Department of Social Medicine and Public Health, Medical University of Warsaw, Warsaw, Poland.
Insights
Congenital herpes simplex virus (cHSV) infection incidence in Poland decreased from 2015-2019. Higher cHSV rates were found in urban areas compared to rural regions, indicating multifactorial causes.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health Epidemiology
Background:
- Congenital herpes simplex virus (cHSV) infection is a rare but severe condition in newborns.
- Understanding recent cHSV trends in Poland is crucial for public health and clinical management.
Purpose of the Study:
- To evaluate the incidence and epidemiological factors of congenital herpes simplex virus infection in Poland between 2014 and 2019.
Main Methods:
- A retrospective, population-based study utilizing hospital discharge records.
- Data were collected from the National Institute of Public Health NIH - National Research Institute, Poland.
Main Results:
- The study included 1,573 newborns with cHSV. The overall incidence was 69 per 100,000 live births.
- A significant decreasing trend in cHSV incidence was observed from 2015-2019 (P<0.01).
- Urban areas showed significantly higher cHSV incidence (88/100,000) than rural areas (40/100,000).
Conclusions:
- The incidence of cHSV is influenced by multifactorial conditions.
- Further research is necessary to understand the evolving patterns of cHSV incidence.
Introduction And Objective:
Congenital herpes simplex virus infection (cHSV) is a rare entity and may pose a life-threatening disease for the newborns. Due to the public health and clinical importance of cHSV infection in infants, the recent data on this disease in Poland should be investigated. The aim of the study was to evaluate the incidence and other factors related to cHSV.
Material And Methods:
The study is retrospective, population-based that utilised the hospital discharge records of cHSV patients. Data were obtained from National Institute of Public Health NIH - National Research Institute in Warsaw, Poland, covering the period 2014-2019.
Results:
The study group consisted of 1,573 cHSV newborns (841 males and 732 females). Among this group, 70.1% were infants up to 90 days of age and 3.6% were neonates up to 28 days of age. The mean and median age was 98 days (95% CI: 94.5-101.8, SD 74) and 70 days (IQR: 53-104), respectively. Based on the hospital registry the overall average cHSV incidence over the study period was estimated to be 69 per 100,000 live births. The number of cHSV infection fluctuated over the years 2014-2019 with a significant decreasing trend from 2015-2019 (P<0.01). A significantly higher cHSV incidence was observed among patients from urban than rural areas of Poland (88 vs 40/100,000 live births; P<0.001).
Conclusions:
CHSV incidence may be related to multifactorial conditions for the occurrence of this disease. Further studies on changes in the incidence of cHSV are needed.
Related Concept Videos
01:26Sexually Transmitted Infections
01:22Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...