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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Cells and Tissue01:30

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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The Bone Matrix01:18

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Bone as Supporting Connective Tissue01:23

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
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Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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The Extracellular Matrix01:29

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Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
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Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
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Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

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Multi-functional osteoclasts in matrix-based tissue engineering bone.

Yue-Qi Chen1, Wen-Hui Hu2, Zi-Cai Dong2

  • 1Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi
|December 31, 2021
PubMed
Summary
This summary is machine-generated.

This review explores novel tissue engineering bone scaffolds for large bone defects, focusing on osteoclasts

Keywords:
Bone regenerationMatrix based-tissue engineering boneMicro-environmentOsteoclasts

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Area of Science:

  • Orthopedics
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Large bone defects pose significant challenges in orthopedic treatment.
  • Tissue engineering offers a promising approach for bone regeneration.
  • The development of functional scaffold materials is crucial for effective bone repair.

Purpose of the Study:

  • To review the multi-functional roles of osteoclasts in bone remodeling.
  • To introduce novel matrix-based tissue engineering bone scaffolds utilizing osteoclasts.
  • To provide a potential direction for developing advanced scaffold materials for bone defect treatment.

Main Methods:

  • Literature review summarizing existing research on osteoclasts and tissue engineering.
  • Analysis of matrix-based tissue engineering approaches.
  • Discussion of strategies for preserving pre-osteoclasts and targeting mature osteoclasts.

Main Results:

  • Osteoclasts play diverse roles in bone remodeling, influencing tissue engineering strategies.
  • Matrix-based scaffolds offer a foundation for developing bioactive bone regeneration materials.
  • Targeting osteoclast populations presents a novel avenue for scaffold design.

Conclusions:

  • Novel matrix-based tissue engineering bone scaffolds incorporating osteoclast-targeting strategies show potential for treating bone defects.
  • This approach offers a promising direction for the development of highly bioactive and functional scaffold materials in orthopedic research.