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Updated: Oct 8, 2025
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Clinical Significance of Serglycin Expression in Human Breast Cancer Patients
Keiko Hosoya1,2, Kanae Nosaka1, Tomohiko Sakabe1
1Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Japan.
Background/Aim:
Serglycin plays a crucial role in the aggressiveness of several types of malignancies, including breast cancer. In this study, we aimed to investigate the prognostic impact of serglycin expression in breast cancer patients, which has not been previously reported.
Patients And Methods:
Immunohistochemical analyses were performed on 348 resected specimens of invasive carcinomas, using antibodies against serglycin.
Results:
Low serglycin expression was observed in 23% of specimens (80/348) and significantly correlated with high histological grade (p=0.001) and negative ER (p=0.013). The log-rank test showed that low serglycin expression correlated with shorter distant metastasis-free survival (DMFS) (p=0.016) and disease-specific survival (DSS) (p=0.037) in node-positive breast cancer patients. Cox's multivariate analysis revealed that low serglycin expression was an independent factor for shorter DMFS (p=0.017) and DSS (p=0.020) in node-positive breast cancer patients.
Conclusion:
Low serglycin expression is an independent predictor of unfavorable prognosis in node-positive breast cancer patients.
