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Preoperative Masseter Muscle Sarcopenia Predicts Mortality in Patients With Oesophageal Cancer
Teppei Kamada1,2, Hironori Ohdaira3, Eisaku Ito3,2
1Department of Surgery, International University of Health and Welfare Hospital, Tochigi, Japan teppei0911show@yahoo.co.jp.
Background/Aim:
The impact of masseter muscle sarcopenia on the prognosis of patients with oesophageal cancer after oesophagectomy remains unclear.
Patients And Methods:
We retrospectively analysed data from 70 patients with oesophageal cancer who underwent oesophagectomy between 2013 and 2019. Overall survival and disease-free survival rates were analysed using Cox proportional hazards models and Kaplan-Meier curves with the log-rank test.
Results:
Masseter muscle sarcopenia was diagnosed in 36 patients. Multivariate analysis identified cytokeratin 19 fragment >1.1 (p=0.04); stage II, III, and IV cancer (p=0.01); and masseter muscle sarcopenia (p<0.01) as significant independent predictors of disease-free survival. Stage II, III, and IV cancer (p<0.01); masseter muscle sarcopenia (p<0.01); and postoperative pneumonia (p<0.01) were significant independent predictors of overall survival.
Conclusion:
Preoperative masseter muscle sarcopenia could be a strong predictor of long-term outcomes in patients who undergo oesophagectomy for oesophageal cancer.
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