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Prognostic Value of Copine 1 in Patients With Renal Cell Carcinoma
Iman M Talaat1,2, Eman Abu-Gharbieh1, Amal Hussein1
1College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Background/Aim:
Renal cell carcinoma (RCC) is among the most common renal malignancies and requires reliable biomarkers for optimum diagnosis and prognosis. Copines are a family of calcium-dependent phospholipid-binding proteins that were reported to be associated with various cancers. We aimed to investigate the prognostic value of Copines 1 and 3 in RCC patients.
Materials And Methods:
Copines 1 and 3 bioinformatics analysis and immunohistochemical (IHC) staining were performed on patients with RCC.
Results:
The findings revealed significant association between Copine 1 expression and the patients' age, nuclear grade, and tumor stage. Bioinformatics analysis showed a similar trend for the mRNA expression of CPNE1, the gene that encodes Copine 1. Interestingly, results revealed a positive association between Copine 1 and both EphA and Ki-67 expression levels. Noteworthy, there was no significant association between Copine 3 expression and any parameters.
Conclusion:
Copine 1 may be used as an independent biomarker or in combination with both EphA2 and Ki-67 to predict disease outcome.
