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Multimodality Characterization of the Clot in Acute Stroke
Daniela Dumitriu LaGrange1, Isabel Wanke2,3,4, Paolo Machi1
1Division of Diagnostic and Interventional Neuroradiology, Diagnostic Department, HUG Geneva University Hospitals, Genève, Switzerland.
Frontiers in Neurology
|December 31, 2021
Summary
Micro-computed tomography (microCT) can reveal clot composition in acute ischemic stroke, aiding treatment understanding. This imaging technique, combined with electron microscopy, offers insights into red blood cell-rich clots and their interaction with stent retrievers.
Area of Science:
- Neurology
- Medical Imaging
- Biomaterials
Background:
- Cerebral vessel occlusion in acute ischemic stroke is treated with endovascular techniques.
- Clot response to treatment varies, necessitating better understanding of clot composition.
- Ex vivo clot characterization can correlate with in vivo imaging features.
Purpose of the Study:
- To explore micro-computed tomography (microCT) and electron microscopy for ex vivo clot characterization.
- To compare microCT and electron microscopy findings with clinical CT scans.
- To investigate microCT as an indicator of clot composition, particularly red blood cell content.
Main Methods:
- Dual-source CT was performed on 16 patients with acute stroke.
- Ex vivo characterization of clots using microCT and electron microscopy.
- Comparison of ex vivo findings with clinical CT imaging features.
Main Results:
- Clinical CT scans showed clots as iso or hyperdense.
- MicroCT findings corroborated clinical CT observations.
- Electron microscopy provided detailed clot composition analysis.
Conclusions:
- MicroCT values can indicate a red blood cell-rich clot composition.
- Combined microCT and electron microscopy provide meaningful data on clot composition.
- This combined approach offers insights into how clots embed within stent retrievers.
