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Related Experiment Videos

[Acute sinusitis in adults].

C Ekedahl

    Infection
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Cefaclor and doxycycline show similar effectiveness in treating acute sinusitis. Cefaclor is a strong alternative to penicillin for purulent sinusitis, especially when penicillin is not suitable.

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    Area of Science:

    • Otolaryngology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Acute sinusitis affects a small percentage of the population, with most cases occurring in adults aged 15-44.
    • Purulent sinusitis requires antibiotic treatment, while non-purulent sinusitis is managed with anti-inflammatory agents.
    • Common bacterial culprits include Haemophilus influenzae, Streptococcus pneumoniae, and anaerobic bacteria.

    Purpose of the Study:

    • To compare the efficacy and safety of cefaclor and doxycycline in treating acute sinusitis.
    • To evaluate cefaclor as an alternative treatment for purulent sinusitis.

    Main Methods:

    • A double-blind study involving 213 patients with acute sinusitis.
    • Patients were randomized to receive either cefaclor (108 patients) or doxycycline (105 patients).

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  • Treatment outcomes were assessed through subjective and objective evaluations, and side-effects were recorded.

    • Main Results:

    • No significant difference was observed between cefaclor and doxycycline in subjective treatment assessments.
    • Objective evaluations showed excellent results for 88% of cefaclor patients and 83% of doxycycline patients.
    • Side-effect incidence was 7% for cefaclor and 13% for doxycycline, with no statistically significant difference.

    Conclusions:

    • Cefaclor demonstrates comparable efficacy to doxycycline in acute sinusitis management.
    • Cefaclor is a valuable second-line option for purulent sinusitis, particularly in cases of penicillin allergy or treatment failure.
    • Both antibiotics are effective, but cefaclor presents a favorable profile considering efficacy, side effects, and ecological factors.