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Therapeutic agents affecting the immune system and drug-induced inflammatory bowel disease (IBD): A review on

Rachele Del Sordo1, Vassilios Lougaris2, Gabrio Bassotti3

  • 1Department of Medicine and Surgery, Section of Anatomic Pathology and Histology, Medical School, University of Perugia, Perugia, Italy.

Clinical Immunology (Orlando, Fla.)
|December 31, 2021
PubMed

In recent years, therapeutic agents affecting the immune system have been largely implemented in the treatment of various hematological, rheumatological and dermatological disorders. Their clinical use has offered important benefits for affected patients and has also ameliorated clinical outcome and prognosis in many cases. Nonetheless, as any treatment, the use of these drugs may be associated with side effects. One of the target organs in such cases is the gastrointestinal tract. In particular, the exacerbation or the onset of inflammatory bowel disease (IBD) in treated patients is not infrequent, although the mechanism of action of these agents may be different. In this review we will focus on the use of therapeutic agents affecting the immune system and the development or exacerbation of IBD, with a mention on the possible underlying pathogenetic mechanisms.

Keywords:
Crohn's diseaseDrugsInflammatory bowel diseaseUlcerative colitis

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