Facilitating cancer systems epidemiology research.

Area of Science:

• Public Health
• Epidemiology
• Cancer Research

Background:

• Traditional epidemiological studies often simplify complex cancer etiology.
• Systems epidemiology offers a holistic approach to cancer research by considering high-dimensional data and inter-relationships.
• This approach aims to provide a broader understanding of cancer complexity.

Purpose of the Study:

• To discuss opportunities and challenges in applying systems epidemiology to cancer research.
• To summarize key themes from a National Cancer Institute (NCI) workshop on cancer systems epidemiology.
• To highlight future directions and foster the growth of this research area.

Main Methods:

• A workshop was convened by the NCI in February 2019.
• Discussions focused on the application of systems epidemiology in cancer research.
• Key themes were identified and summarized in this manuscript.

Main Results:

• Eight key themes emerged: transdisciplinary collaboration, methods and modeling, interpretation and validation, data needs, data sharing, training, model dissemination, and community building.
• Opportunities for cancer systems epidemiology research were identified.
• A collection of papers on "Cancer System Epidemiology Insights and Future Opportunities" was introduced.

Conclusions:

• Systems epidemiology offers a powerful framework for understanding cancer complexity.
• Fostering transdisciplinary collaboration, data sharing, and enhanced training is crucial.
• Continued development and application of systems epidemiology will advance cancer research.