Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.6K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

16.7K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
16.7K
Human Genetics01:28

Human Genetics

793
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
793

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variability in the effects of ketamine enantiomers across animal models of depression and implications for human studies.

British journal of pharmacology·2026
Same author

Age-dependent acceleration of structural brain aging in medication-free major depressive disorder linked to neuroanatomical phenotype findings from COORDINATE-MDD consortium.

medRxiv : the preprint server for health sciences·2026
Same author

Differential effects of ketamine enantiomers on EEG parameters including the gamma-delta shift phenomenon.

British journal of pharmacology·2026
Same author

Cryopreservation and In Vitro Culture of Isolated Porcine Ovarian Follicles.

Veterinary sciences·2026
Same author

Genetic differences in familial adenomatous polyposis syndrome in a Hungarian population: A prospective single center study.

World journal of gastroenterology·2026
Same author

Reproductive support of a valuable canine colony with assisted reproductive technique - Short communication.

Acta veterinaria Hungarica·2025

Related Experiment Video

Updated: Oct 8, 2025

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
16:13

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

20.2K

A replication study separates polymorphisms behind migraine with and without depression.

Peter Petschner1,2,3, Daniel Baksa2,4, Gabor Hullam5

  • 1Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, Japan.

Plos One
|December 31, 2021
PubMed
Summary

This study replicated key migraine-associated genes in a European cohort, identifying specific genetic variants in PRDM16 and the 1p31.1 region. These findings highlight potential genetic underpinnings, particularly in individuals with comorbid depression.

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.0K
Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.0K

Related Experiment Videos

Last Updated: Oct 8, 2025

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
16:13

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Published on: June 13, 2011

20.2K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.0K
Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.0K

Area of Science:

  • Genetics
  • Neuroscience
  • Epidemiology

Background:

  • Migraine is a complex neurological disorder with a significant genetic component.
  • Genome-wide association studies (GWAS) have identified numerous candidate migraine loci.
  • The role of these loci and their interaction with comorbid conditions like depression requires further investigation.

Purpose of the Study:

  • To replicate findings from a large GWAS of migraine in a European cohort.
  • To investigate the influence of lifetime depression on the genetic associations with migraine.
  • To identify specific genes and genetic variants contributing to migraine pathophysiology.

Main Methods:

  • Genotyping of single nucleotide polymorphisms (SNPs) within identified candidate loci and their vicinity.
  • Regression models to assess main effects and gene-depression interactions.
  • Advanced statistical analyses including Bayesian relevance analysis and neural network classification.

Main Results:

  • Replication of significant associations for PRDM16 (rs2455107) and several intergenic SNPs in the 1p31.1 region.
  • Identification of both risk and protective variants within the 1p31.1 region.
  • Significant interaction effects involving genes such as ADGRL2, REST, and HPSE2, particularly with comorbid depression.

Conclusions:

  • The 1p31.1 region and PRDM16 gene are confirmed as relevant in migraine.
  • REST, HPSE2, and ADGRL2 are identified as potential key genes in migraine pathophysiology, especially in patients with depression.
  • Advanced analytical methods enhance the predictive power of genetic findings in migraine.