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Published on: May 17, 2019
Prognostic Significance of p16 Protein Expression in Breast Cancer
Magdi M Salih1, Amjed A Higgo2, Emad M Eed3
1Department of Clinical Laboratory Science, College of Applied Medical Sciences, Taif University, Taif, Kingdom of Saudi Arabia; Magdi-206@hotmail.com.
Background/Aim:
Breast cancer is the most common cancer in Sudan. The p16 protein plays a vital role in the regulation of the cell cycle.
Patients And Methods:
This study analysed the protein expression of p16 in 202 paraffin blocks from Sudanese women with breast cancer using immunohistochemistry.
Results:
This study included 168 (83.2%), 16 (7.9%), and 18 (8.9%) patients with invasive ductal carcinoma, invasive lobular carcinoma, and papillary carcinoma, respectively. There were 95 cases (47.0%) with grade III, 70 cases (34.6%) with grade II, and 23 cases (11.4%) with grade I breast cancer. The hormone receptor status was available for 119 of the cases, and 31 (15.3%), 25 (12.4%), and 63 (31.2%) cases were positive for oestrogen, progesterone, and HER2 receptors, respectively.
Conclusion:
p16 protein expression was associated with high histologic grade, lymph node metastasis, and poor prognosis. p16 protein expression may potentially be used as a prognostic marker.
