Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Intralumenal Vesicles and Multivesicular Bodies

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...

Overview of Secretory Vesicles

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Large-scale discovery platform enables identification of peptides targeting drug-resistant candidiasis.

Cell reports methods·2026

Same author

Protein-related hydrophobicity differences among strains belonging to <i>Candidozyma auris</i> (<i>Candida auris</i>) clades.

Microbiology spectrum·2026

Same author

Understanding <i>Candidozyma</i> (<i>Candida) auris:</i> genomic evolution, antifungal resistance and the growing challenges in global infection control.

Journal of medical microbiology·2026

Same author

Correction: Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation.

PLoS pathogens·2026

Same author

Caspofungin Reshapes the Extracellular Vesicles Metabolome of <i>Candidozyma</i> (<i>Candida</i>) <i>auris</i>, Altering Amino Acid and Nucleotide Metabolism.

Journal of fungi (Basel, Switzerland)·2026

Same author

Extracellular vesicles of <i>Emergomyces africanus</i> modulate host immune responses and reflect metabolic adaptations to nutrient availability.

Infection and immunity·2026

Search research articles

Related Experiment Video

Updated: Oct 8, 2025

Purification of High Yield Extracellular Vesicle Preparations Away from Virus

Purification of High Yield Extracellular Vesicle Preparations Away from Virus

Published on: September 12, 2019

Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles.

Daniel Zamith-Miranda¹, Lysangela Ronalte Alves², Ernesto Satoshi Nakayasu³

¹Albert Einstein College of Medicine, Bronx, NY, USA.

Current Topics in Microbiology and Immunology

|January 1, 2022

Summary

Histoplasma capsulatum produces extracellular vesicles (EV) containing virulence factors. The fungus regulates EV loading and release based on its environment, impacting pathogenesis.

Keywords:

Extracellular vesicles Histoplasma capsulatum Proteomics Serology

More Related Videos

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

Mycobacterium tuberculosis Extracellular Vesicle Enrichment through Size Exclusion Chromatography

Mycobacterium tuberculosis Extracellular Vesicle Enrichment through Size Exclusion Chromatography

Published on: May 19, 2022

Related Experiment Videos

Last Updated: Oct 8, 2025

Purification of High Yield Extracellular Vesicle Preparations Away from Virus

Purification of High Yield Extracellular Vesicle Preparations Away from Virus

Published on: September 12, 2019

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

Mycobacterium tuberculosis Extracellular Vesicle Enrichment through Size Exclusion Chromatography

Mycobacterium tuberculosis Extracellular Vesicle Enrichment through Size Exclusion Chromatography

Published on: May 19, 2022

Area of Science:

Mycology
Infectious Diseases
Cell Biology

Background:

Histoplasma capsulatum is a significant cause of endemic mycosis.
Fungal extracellular vesicles (EV) are increasingly recognized for their role in pathogenesis.
Understanding EV production is crucial for developing targeted therapies.

Purpose of the Study:

To detail current knowledge of EV biology in Histoplasma capsulatum.
To explore the impact of EV on fungal virulence and pathogenesis.
To understand the dynamic regulation of EV loading and release.

Main Methods:

Review of laboratory findings on Histoplasma capsulatum EV production.
Analysis of compounds within fungal EV.
Investigation of environmental stimuli affecting EV release.

Main Results:

Histoplasma capsulatum actively produces extracellular vesicles.
These EVs are reservoirs of diverse compounds influencing fungal virulence.
EV production and content are dynamically regulated by growth conditions and stimuli.

Conclusions:

Fungal EV play a critical role in Histoplasma capsulatum pathogenesis.
Dynamic regulation of EV biology is a key aspect of H. capsulatum virulence.
Further research into H. capsulatum EV offers therapeutic potential.