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Fungal Extracellular Vesicles as a Potential Strategy for Vaccine Development

Leandro Honorato1, Jhon Jhamilton Artunduaga Bonilla1, Alicia C Piffer1

  • 1Instituto de Microbiologia Paulo de Góes, Departamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Current Topics in Microbiology and Immunology
|January 1, 2022
PubMed

Insights

Fungal extracellular vesicles (EVs) carry immune-stimulating molecules. These fungal EVs show promise as a novel platform for developing effective antifungal vaccines against infections.

Area of Science:

  • Mycology
  • Immunology
  • Biotechnology

Background:

  • Extracellular vesicles (EVs) are released by all live cells, including fungi.
  • Fungal EVs can interact with host cells and influence disease progression.
  • These vesicles contain lipids, proteins, polysaccharides, glycans, nucleic acids, and metabolites.

Purpose of the Study:

  • To discuss the potential of fungal EVs as a platform for antifungal vaccine development.
  • To highlight the immunogenic properties of molecules carried by fungal EVs.

Main Methods:

  • Compositional analysis of fungal EVs.
  • Characterization of immunogenic molecules within EVs.
  • Assessment of immune cell stimulation and antibody production.

Main Results:

  • Fungal EVs contain various biomolecules, including those with immunogenic properties.
  • These EVs stimulate innate immune cells and induce antibody production.
  • Fungal EVs demonstrated protective effects against fungal infections in insect and mouse models.

Conclusions:

  • Fungal EVs possess inherent immunomodulatory capabilities.
  • The diverse cargo of fungal EVs makes them a versatile platform for vaccine development.
  • Utilizing fungal EVs offers a novel strategy for creating next-generation antifungal vaccines.

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