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Pulmonary Toxicities of Immunotherapy

Mehmet Altan1, Linda Zhong2, Vickie R Shannon3

  • 1Thoracic/Head & Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. maltan@mdanderson.org.

Advances in Experimental Medicine and Biology
|January 1, 2022
PubMed

Immune checkpoint inhibitors are a form of immunotherapy that are increasingly being used in a wide variety of cancers. Immune-related adverse events (irAEs) pose a major challenge in the treatment of cancer patients. Pneumonitis, the most common lung irAE, can cause significant disruptions in the treatment of cancer and may be life-threatening. The goal of this chapter is to instruct readers on the incidence and clinical manifestations of pneumonitis and to offer guidance in the evaluation and treatment of patients with pneumonitis.

Keywords:
Checkpoint inhibitorsDiffuse alveolar damageHypersensitivity pneumonitisImmune-related adverse eventNonspecific interstitial pneumoniaOrganizing pneumoniaPneumonitisThoracic imaging

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