Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robust Hybrid Plasmon-Photon Modes in Colloidal Metasurfaces Probed by Angle-Resolved SERS.

ACS applied materials & interfaces·2026
Same author

A connectome-based neural correlate of pediatric ADHD hyperactivity-impulsivity symptoms.

Frontiers in psychiatry·2026
Same author

Left-lateralized glymphatic dysfunction is associated with MoCA-measured cognitive impairment in cerebral small vessel disease: A DTI-ALPS study.

IBRO neuroscience reports·2026
Same author

Adenosquamous carcinoma of the lung: Comparative CT and pathological features versus adenocarcinoma and squamous cell carcinoma.

PloS one·2026
Same author

Multi-kingdom gut microbiota analysis identifies bacterial-viral association in multiple myeloma.

Frontiers in microbiology·2026
Same author

Measuring the Impacts of Urbanicity and Different Exposome Factors on Human Brain through Exposure Network Mapping.

Neuroscience bulletin·2026

Related Experiment Video

Updated: Oct 8, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.4K

Exosomal targeting and its potential clinical application.

Jiao He1, Weihong Ren2, Wei Wang3

  • 1The First Clinical Medical Institute, Henan University of Chinese Medicine, Zhengzhou, Henan, People's Republic of China.

Drug Delivery and Translational Research
|January 1, 2022
PubMed
Summary
This summary is machine-generated.

Exosomes, natural nano-carriers, show promise for targeted drug delivery. Engineering exosomes enhances their targeting capabilities for improved clinical applications.

Keywords:
EngineeringExosomesTargetingTransformation

More Related Videos

Formulating and Characterizing an Exosome-based Dopamine Carrier System
06:08

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Published on: April 4, 2022

3.3K
Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

926

Related Experiment Videos

Last Updated: Oct 8, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells
09:59

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

25.4K
Formulating and Characterizing an Exosome-based Dopamine Carrier System
06:08

Formulating and Characterizing an Exosome-based Dopamine Carrier System

Published on: April 4, 2022

3.3K
Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

926

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Cell Biology

Background:

  • Exosomes are natural nano-carriers secreted by cells.
  • They possess inherent targeting capabilities due to surface molecules like tetraspanins and integrins.
  • Exosomes are increasingly utilized as drug delivery systems due to their biocompatibility and efficacy.

Purpose of the Study:

  • To review the research progress on the natural targeting of exosomes.
  • To discuss strategies for engineering exosomes to enhance their targeting precision.
  • To explore the mechanisms of both natural and engineered exosome targeting.

Main Methods:

  • Literature review of studies on exosome targeting.
  • Analysis of exosome surface molecules and their role in natural targeting.
  • Examination of exosome engineering techniques for improved targeting.
  • Discussion of clinical applications and challenges.

Main Results:

  • Exosomes exhibit natural cell targeting influenced by surface proteins.
  • Current natural targeting is insufficient for precise clinical delivery.
  • Exosome engineering significantly enhances targeting accuracy and therapeutic potential.
  • Combined therapeutic strategies using engineered exosomes show promise.

Conclusions:

  • Exosomes are valuable drug delivery vehicles with natural targeting properties.
  • Engineering exosomes is crucial for overcoming limitations in precise targeting.
  • Optimized exosome targeting holds significant potential for clinical applications, particularly in oncology.