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Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering.

Qian Yang1, Jinrong Peng2, Haitao Xiao3

  • 1Center of Scientific Research, Chengdu Medical College, Chengdu, Sichuan 610500, PR China; Laboratory of Plastic Surgery and Burns, Department of Plastic Surgery and Burns, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.

Carbohydrate Polymers
|January 2, 2022
PubMed
Summary

Polysaccharide hydrogels are versatile biomaterials for tissue engineering. Modifications enhance their function in cell delivery, tissue regeneration, and reducing foreign-body response (FBR).

Keywords:
Cell scaffoldsForeign body responseGelation mechanismPolysaccharide hydrogelsTissue regeneration

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Polysaccharide hydrogels are crucial in tissue engineering due to their biocompatibility and ability to interact with biological systems.
  • These hydrogels can modulate drug delivery and support long-term cell viability and function.
  • Modifications are key to tailoring their properties for specific biomedical applications.

Purpose of the Study:

  • To review strategies for modifying polysaccharides to create advanced hydrogels for tissue engineering.
  • To summarize methods for polysaccharide hydrogel formation and their underlying mechanisms.
  • To highlight the in vivo applications of these hydrogels, focusing on foreign-body response (FBR) mitigation and tissue regeneration.

Main Methods:

  • Review of literature on polysaccharide modification techniques.
  • Summary of hydrogel formation mechanisms for polysaccharides and their derivatives.
  • Analysis of in vivo studies on polysaccharide hydrogels for FBR and tissue regeneration.

Main Results:

  • Polysaccharide modification offers versatile strategies for functionalization and cell behavior regulation.
  • Various techniques exist for inducing hydrogel formation from polysaccharides.
  • Polysaccharide hydrogels demonstrate efficacy in alleviating FBR and serving as scaffolds for tissue regeneration in vivo.

Conclusions:

  • Polysaccharide hydrogels hold significant potential in tissue engineering.
  • Further research is needed to address challenges and fully exploit their capabilities.
  • Optimized polysaccharide hydrogels can advance regenerative medicine and biomaterial applications.