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Which will carry more weight when CTR > 0.5, solid component size, CTR, tumor size or SUVmax?

Shaoyuan Zhang1, Dong Lin2, Yangli Yu3

  • 1Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Lung Cancer (Amsterdam, Netherlands)
|January 2, 2022
PubMed
Summary
This summary is machine-generated.

Maximum standard uptake value (SUVmax) predicts high-risk subtypes and node metastasis in early-stage lung adenocarcinoma. Higher SUVmax is linked to poorer survival, aiding in risk stratification for these lung cancers.

Keywords:
18F-FDG uptakeLung adenocarcinomaPathological subtypeSUVmax

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Area of Science:

  • Oncology
  • Radiology
  • Pulmonology

Background:

  • Investigating the clinical significance of maximum standard uptake value (SUVmax) in early-stage lung adenocarcinoma (clinical stage IA, tumor size ≤ 2 cm, consolidation to tumor ratio (CTR) > 0.5).
  • Differentiating between part-solid and pure-solid nodules based on CTR to assess prognostic factors.

Purpose of the Study:

  • To explore the clinical significance of SUVmax in predicting high-risk subtypes and outcomes in clinical stage IA lung adenocarcinoma.
  • To analyze the association between SUVmax, high-risk features, nodal metastasis, and long-term survival.

Main Methods:

  • Retrospective review of 270 non-small cell lung cancer patients who underwent surgery.
  • Classification of nodules into part-solid (0.5 < CTR < 1) and pure-solid (CTR = 1) groups.
  • Analysis of SUVmax, high-risk subtypes, nodal status, and 5-year relapse-free and overall survival using time-dependent ROC curves and multivariable analysis.

Main Results:

  • Significant differences in pathological subtypes, SUVmax, and N stage between part-solid and pure-solid nodules.
  • SUVmax independently predicted high-risk subtypes in part-solid nodules and both high-risk subtypes and node metastasis in pure-solid nodules.
  • SUVmax thresholds (≥2.6 and ≥5.1) were strongly associated with 5-year relapse-free and overall survival, respectively.

Conclusions:

  • Part-solid and pure-solid lung adenocarcinomas exhibit distinct clinicopathological characteristics, particularly concerning SUVmax.
  • SUVmax is a significant predictor of high-risk subtypes, nodal metastasis, and both relapse-free and overall survival in early-stage lung adenocarcinoma.