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The relationship between mean platelet volume and resistant hypertension
Halil Akın1, Önder Bilge2, Bünyamin Yavuz3
1Department of Cardiology, Private Medicalpark Hospital, Ankara, Turkey.
Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|January 3, 2022
Summary
Higher mean platelet volume (MPV) indicates platelet activation and is linked to cardiovascular risk. This study found elevated MPV in resistant hypertension patients, suggesting it may predict adverse cardiovascular events.
Area of Science:
- Cardiology
- Hematology
- Hypertension Research
Background:
- Resistant hypertension (RH) significantly elevates cardiovascular event risk.
- Mean platelet volume (MPV) is an indicator of platelet activation and a marker for cardiovascular disease risk.
Purpose of the Study:
- To investigate the association between mean platelet volume (MPV) and resistant hypertension (RH).
Main Methods:
- A study involving 279 participants divided into three groups: resistant hypertension (n=78), controlled hypertension (n=79), and normotensive individuals (n=105).
- Data collected included routine laboratory tests and ambulatory blood pressure monitoring (ABPM).
Main Results:
- Mean MPV was highest in the resistant hypertension group (9.34 ± 1.49 fL), followed by the controlled hypertension group (8.82 ± 0.83 fL), and the normotensive group (8.5 ± 0.85 fL).
- A significant difference in MPV was observed between the resistant hypertension group and both the controlled hypertension (p=0.008) and normotensive groups (p<0.001).
- No significant MPV difference was found between controlled hypertensive and normotensive individuals (p=0.157).
Conclusions:
- Mean platelet volume is significantly higher in patients with resistant hypertension compared to those with controlled hypertension or normal blood pressure.
- Elevated MPV may serve as a predictive marker for adverse cardiovascular events in individuals with resistant hypertension.
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