Clear Aligners in Patients with Amelogenesis and Dentinogenesis Imperfecta

Area of Science:

• Dental Genetics
• Orthodontics
• Biomaterials Science

Background:

• Dentinogenesis imperfecta (DI) and amelogenesis imperfecta (AI) are hereditary dental hard tissue disorders.
• These conditions significantly impact socialization, function, and comfort, necessitating early diagnosis and management.
• DI and AI can co-occur with other genetic disorders like osteogenesis imperfecta.

Purpose of the Study:

• To review the current evidence on the application of clear aligner therapy (CAT) in patients with amelogenesis imperfecta (AI) and dentinogenesis imperfecta (DI).
• To evaluate the efficacy and suitability of CAT as an orthodontic treatment for AI and DI.
• To highlight the limitations and future research directions for CAT in managing these rare dental anomalies.

Main Methods:

• Systematic review of existing literature on orthodontic management of AI and DI.
• Analysis of studies comparing different orthodontic approaches, including fixed appliances and CAT.
• Evaluation of the benefits and drawbacks of CAT in the context of AI and DI treatment.

Main Results:

• Clear aligner therapy (CAT) presents potential advantages over fixed appliances for patients with AI and DI.
• The current evidence base for CAT in AI and DI is limited and heterogeneous.
• Further research is required to establish robust clinical guidelines for CAT in these patient populations.

Conclusions:

• Interdisciplinary treatment combining orthodontic, prosthodontic, and periodontic approaches improves outcomes for AI and DI.
• CAT is a favorable orthodontic option for AI and DI, but requires more supporting evidence.
• Future studies should focus on the long-term efficacy and patient-reported outcomes of CAT in AI and DI management.