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Clinical and Epidemiological Characteristics of Coronavirus Disease 2019 in Iran: a Hospital-Based Observational

Ilad Alavi Darazam^1,2, Sajad Besharati^1,2, Minoosh Shabani^1,2

¹Clinical Research Development Unit of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

|January 3, 2022

Insights

This study analyzed the clinical and epidemiological features of 394 hospitalized Coronavirus disease 2019 (COVID-19) patients in Iran. Findings reveal hospitalization peaks and specific clinical abnormalities to aid outbreak management.

Area of Science:

Epidemiology
Infectious Diseases
Public Health

Background:

Coronavirus disease 2019 (COVID-19) presents a global health burden with many aspects poorly understood.
Understanding COVID-19's clinical and epidemiological characteristics is crucial for effective outbreak management.

Purpose of the Study:

To investigate the clinical and epidemiological characteristics of COVID-19.
To provide data to assist the Iranian health system in managing the COVID-19 outbreak.

Main Methods:

Retrospective observational study of 394 hospitalized COVID-19 patients.
Data collected over 10 weeks from Loghman-Hakim hospital, Tehran, Iran.
Documented demographic, clinical, and paraclinical information, including morbidity and mortality.

Main Results:

Hospitalization rates followed a bell curve, peaking in the 4th week.
Highest rates of secondary adverse events occurred in weeks 6 and 7.
Clinical findings included bilateral lung opacity on CT scans and low oxygen saturation.

Conclusions:

This study characterizes the initial phase of the COVID-19 outbreak in Iran.
Further research comparing different outbreak phases is recommended for comprehensive understanding.

Read full analysis

Abstract

Background:

Coronavirus disease 2019 (COVID-19) has been pandemic and has caused a great burden on almost all countries across the world. Different perspectives of this novel disease are poorly understood. This study sought to investigate the clinical and epidemiological characteristics of COVID-19 to efficiently assist the health system of Iran to conquer the outbreak.

Materials And Methods:

This retrospective observational study was performed on 394 patients with a diagnosis of COVID-19. The patients should have a history of hospitalization at Loghman-Hakim hospital, Tehran, Iran, for 10 weeks, beginning from the first official report of the disease in Iran. In the subsequent step, the baseline demographic and clinical and paraclinical information of the patients was documented. Finally, the patients were assessed if they had exhibited any morbidity or mortality.

Results:

The epidemiological examination of the COVID-19 population suggested a bell diagram pattern for the hospitalization rate, in which the 4th week of the study was the peak. The highest rate of secondary adverse events due to the virus was observed at the 6th and 7th weeks of the study course. On another note, clinical evaluations resulted in identifying specific abnormalities, such as bilateral opacity in chest computed tomography scans or low oxygen saturation in laboratory data.

Conclusion:

This study provides evidence concerning the clinical and epidemiological characteristics of COVID-19 in the first phase of the virus outbreak in Iran. Further studies comparing the disease features in the subsequent phases with findings of this study can pave the way for additional information in this regard.

Keywords:

COVID-19 Iran Loghman-Hakim Hospital Morbidity Mortality Observational Study

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