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The roles of long non-coding RNAs in lung cancer

Zhe Cao1, Linda Oyang1, Xia Luo1

  • 1Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.

Journal of Cancer
|January 3, 2022
PubMed

Insights

Long non-coding RNAs (lncRNAs) play a crucial role in lung cancer development. Understanding these molecules offers new diagnostic and therapeutic strategies for this common malignancy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer is a leading cause of cancer-related mortality worldwide.
  • Current treatments, including targeted therapies, have limited impact on overall survival rates.
  • There is a critical need for novel biomarkers and therapeutic targets for improved lung cancer management.

Purpose of the Study:

  • To review characterized long non-coding RNAs (lncRNAs) implicated in lung cancer pathogenesis.
  • To discuss the translational potential of lncRNAs in clinical applications for lung cancer.

Main Methods:

  • Literature review of studies on lncRNAs in lung cancer.
  • Analysis of lncRNA functions at transcriptional, translational, and post-translational levels.
  • Evaluation of lncRNAs as diagnostic, prognostic, and therapeutic targets.

Main Results:

  • lncRNAs are extensively involved in the molecular mechanisms of lung cancer.
  • Specific lncRNAs have been identified and characterized in lung cancer.
  • These lncRNAs demonstrate potential as biomarkers and therapeutic targets.

Conclusions:

  • lncRNAs represent a promising area for advancing lung cancer research.
  • Further investigation into lncRNA functions can lead to improved early diagnosis, treatment, and prognosis.
  • Translational studies are essential to integrate lncRNAs into clinical practice for lung cancer patients.
Keywords:
LncRNAsMALAT1and HOTAIRlung cancertumor biomarkers

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