Related Experiment Video
Updated: Oct 8, 2025

A Two-Step Method for Percutaneous Transhepatic Choledochoscopic Lithotomy
Published on: September 13, 2022
Symptomatic Gallstones in Young Patients Under the Age of 30 Years
Asif Ali1, Sughra Perveen2, Imran Khan2
1Department of Surgery, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Insights
Young adults are increasingly experiencing symptomatic gallstones, particularly females. Risk factors include obesity, high cholesterol, and high triglycerides, highlighting the need for further research into causes.
Area of Science:
- Gastroenterology and Hepatology
- Surgical Research
Background:
- Gallstones, hardened digestive fluid deposits, can be symptomatic or asymptomatic.
- Understanding the characteristics of symptomatic gallstones in younger populations is crucial for early diagnosis and management.
Purpose of the Study:
- To assess the sociodemographic and clinical characteristics of patients under 30 with symptomatic gallstones.
- To identify potential risk factors associated with symptomatic gallstones in this age group.
Main Methods:
- A prospective, observational study was conducted over one year at Jinnah Postgraduate Medical Centre, Pakistan.
- Ultrasonic examination was used for diagnosis, followed by cholecystectomy (laparoscopic or open) for treatment.
- Data collected included age, medical history (oral contraceptive use, pregnancy), socioeconomic status, and body mass index (BMI).
Main Results:
- 210 patients under 30 were included, with a mean age of 25 ± 3 years; 81% were female.
- Identified risk factors included oral contraceptive use (31.84%), recent pregnancy (32.96%), diabetes mellitus (20.48%), and overweight/obesity (54.29% with BMI 25-30 kg/m²).
- Elevated triglyceride (51.43%) and cholesterol (54.76%) levels were prevalent, suggesting a link to symptomatic gallstones in younger individuals.
Conclusions:
- Young adults are susceptible to symptomatic gallstones.
- Females, and those with high cholesterol, high triglycerides, and abnormal BMI, show a higher incidence.
- Further research is warranted to elucidate the specific causes of gallstones in this demographic.
Abstract:
Introduction Gallstones are deposits of digestive fluid that is hardened into small pellets. Gallstones can be symptomatic or asymptomatic. The present study assessed the sociodemographic and clinical characteristics of patients under the age of 30 years old with symptomatic gallstones. Methodology A prospective, observational study was conducted at Surgical Unit-3, at Jinnah Postgraduate Medical Centre (JPMC), Pakistan, from July 2020 to July 2021. All patients suspected of having gallstone disease underwent ultrasonic examination. A diagnosis of gallstone disease was made if the gallbladder showed a hyperechoic mass casting a posterior acoustic shadow, with a change of position. All of the patients with gallstone disease were hospitalized. The patients were asked about their age, past history (with special emphasis on last pregnancy and years of oral contraceptive use, if any), socioeconomic status, and other demographic data. The patients were treated with a cholecystectomy, either laparoscopic or open. Postcholecystectomy complications, if any, were recorded. Results A total of 210 patients under the age of 30 years were included. The mean age of patients was 25 ± 3 years. The majority of the population were females, i.e., 170 (81%). Upon assessing the risk factors, it was found that 31.84% of the female patients had used oral contraceptives, 32.96% were pregnant at the time of presentation, 20.48% had diabetes mellitus, and 27.14% had a history of gallstones. Furthermore, it was found that about 114 (54.29%) patients were overweight with a body mass index (BMI) of 25-30 kg/m2. High triglyceride levels and high cholesterol levels were found in 108 (51.43%) and 115 (54.76%) of the patients, respectively, indicating a link between symptomatic gallstones and younger age. Conclusion Our study indicated that young people are prone to symptomatic gallstones. The rate of disease was considerably high among females and in patients with high cholesterol and triglyceride levels and abnormal body mass index. Further exploratory studies are needed to determine the cause of gallstones.
Related Concept Videos
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Gallbladder
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Acute Pancreatitis II: Clinical Manifestations and Management
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...

