Symptomatic Gallstones in Young Patients Under the Age of 30 Years

Asif Ali1, Sughra Perveen2, Imran Khan2

  • 1Department of Surgery, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Cureus
|January 3, 2022
PubMed

Insights

Young adults are increasingly experiencing symptomatic gallstones, particularly females. Risk factors include obesity, high cholesterol, and high triglycerides, highlighting the need for further research into causes.

Area of Science:

  • Gastroenterology and Hepatology
  • Surgical Research

Background:

  • Gallstones, hardened digestive fluid deposits, can be symptomatic or asymptomatic.
  • Understanding the characteristics of symptomatic gallstones in younger populations is crucial for early diagnosis and management.

Purpose of the Study:

  • To assess the sociodemographic and clinical characteristics of patients under 30 with symptomatic gallstones.
  • To identify potential risk factors associated with symptomatic gallstones in this age group.

Main Methods:

  • A prospective, observational study was conducted over one year at Jinnah Postgraduate Medical Centre, Pakistan.
  • Ultrasonic examination was used for diagnosis, followed by cholecystectomy (laparoscopic or open) for treatment.
  • Data collected included age, medical history (oral contraceptive use, pregnancy), socioeconomic status, and body mass index (BMI).

Main Results:

  • 210 patients under 30 were included, with a mean age of 25 ± 3 years; 81% were female.
  • Identified risk factors included oral contraceptive use (31.84%), recent pregnancy (32.96%), diabetes mellitus (20.48%), and overweight/obesity (54.29% with BMI 25-30 kg/m²).
  • Elevated triglyceride (51.43%) and cholesterol (54.76%) levels were prevalent, suggesting a link to symptomatic gallstones in younger individuals.

Conclusions:

  • Young adults are susceptible to symptomatic gallstones.
  • Females, and those with high cholesterol, high triglycerides, and abnormal BMI, show a higher incidence.
  • Further research is warranted to elucidate the specific causes of gallstones in this demographic.

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