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The Impact of Charlson Comorbidity Index on Mortality From SARS-CoV-2 Virus Infection

Jawad Ahmed1, Camilo Andrés Avendaño Capriles2,3, Natalia M Avendaño Capriles3

  • 1Medicine, Liaquat National Hospital and Medical College, Karachi, PAK.

Cureus
|January 3, 2022
PubMed

Insights

The Charlson Comorbidity Index (CCI) effectively predicts mortality in hospitalized COVID-19 patients. A new CoLACD score also shows promise in assessing COVID-19 patient mortality risk.

Area of Science:

  • Medical research
  • Epidemiology
  • Clinical outcomes

Background:

  • The Charlson Comorbidity Index (CCI) is a validated tool for assessing mortality risk from comorbid diseases.
  • CCI has been utilized as a predictor of long-term survival and prognosis.

Purpose of the Study:

  • To determine the impact of the CCI score on mortality in hospitalized COVID-19 patients.
  • To evaluate the efficacy of the novel CoLACD score in predicting mortality among these patients.

Main Methods:

  • Retrospective cohort study design.
  • Data collected from two tertiary hospitals in Karachi between January 15, 2021, and April 30, 2021.
  • Inclusion of patients with confirmed COVID-19 infection.

Main Results:

  • Key predictors of mortality identified include CCI score, patient age, D-dimer levels, smoking status, and shortness of breath.
  • The CoLACD score demonstrated 80.23% sensitivity and 50.23% specificity, with a diagnostic accuracy of 60.45%.
  • The positive predictive value (PPV) for the CoLACD score was 83.01%, and the negative predictive value (NPV) was 39.44%.

Conclusions:

  • The Charlson Comorbidity Index (CCI) is a valuable tool for predicting mortality in clinical settings for COVID-19 patients.
  • The CoLACD score shows potential for mortality prediction in hospitalized COVID-19 cases.
Abstract

Keywords:
charlson comorbidity indexcolacdcovid-19impactmortality

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