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CPEB4 Inhibit Cell Proliferation via Upregulating p21 mRNA Stability in Renal Cell Carcinoma

Jiehui Di1,2,3, Hui Wang1,2,3, Zhongjun Zhao1,2,3

  • 1Cancer Institute, Xuzhou Medical University, Xuzhou, China.

Frontiers in Cell and Developmental Biology
|January 3, 2022
PubMed

Insights

Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) acts as a tumor suppressor in renal cell carcinoma (RCC). Low CPEB4 expression correlates with poor prognosis, and it inhibits RCC growth by regulating cell cycle progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) exhibits varied roles across different cancers.
  • The specific function of CPEB4 in renal cell carcinoma (RCC) remains largely undetermined.

Purpose of the Study:

  • To investigate the role and molecular mechanisms of CPEB4 in the development and progression of RCC.
  • To evaluate CPEB4 as a potential prognostic biomarker in RCC patients.

Main Methods:

  • Analysis of CPEB4 expression levels in RCC tissues and cell lines.
  • In vivo and in vitro experiments to assess the impact of CPEB4 on RCC tumor growth.
  • Investigation of CPEB4's effect on p21 mRNA stability and cell cycle regulation.

Main Results:

  • CPEB4 expression is significantly down-regulated in RCC tissues and cell lines.
  • Lower CPEB4 expression is associated with reduced overall and disease-free survival in RCC patients.
  • CPEB4 demonstrates potent inhibition of RCC tumor growth and induces G1 cell cycle arrest by enhancing p21 mRNA stability.

Conclusions:

  • CPEB4 functions as a tumor suppressor gene in RCC, restraining cell cycle progression upstream of p21.
  • CPEB4 holds promise as a predictive biomarker for prognosis in patients with renal cell carcinoma.
Keywords:
CPEB4mRNA stabilityp21proliferationrenal cell carcinoma

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