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Updated: Oct 8, 2025

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

Published on: March 29, 2022

High-Resolution Image Analysis Reveals a Decrease in Lens Thickness and Cone Density in a Cohort of Young Myopic

Xiaoyu Xin^1,2, Qingge Guo^1,2, Shuai Ming^1,2

¹Department of Ophthalmology, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, China.

Frontiers in Medicine

|January 3, 2022

Summary

Axial length in myopia is associated with thinning of the lens, outer retinal layer, and choroid. Cone density also decreases, but visual acuity remains good, suggesting compensatory mechanisms.

Keywords:

adaptive optics cone lens myopia retina

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Published on: October 21, 2022

Area of Science:

Ophthalmology
Biomedical Engineering
Vision Science

Background:

Myopia, or nearsightedness, is a growing global health concern.
Axial elongation is a primary characteristic of myopia.
Understanding the morphological changes associated with myopia is crucial for developing effective interventions.

Purpose of the Study:

To investigate the relationship between axial length (AL) and ocular tissue thickness (lens, retina, choroid) and cone photoreceptor density.
To utilize advanced imaging techniques, swept-source optical coherence tomography (SS-OCT) and adaptive optics (AO) fundus camera, for precise measurements.

Main Methods:

A prospective cross-sectional study involving 136 eyes from 68 subjects.
SS-OCT quantified lens, ganglion cell complex (GCC), inner nuclear layer (INL), outer retinal layer (ORL), and choroid thickness.
AO imaging assessed cone photoreceptor density, spacing, regularity, and dispersion.
Linear regression analyzed associations between AL and measured parameters.

Main Results:

Increased AL in myopia correlated with decreased lens thickness (LT), ORL, and choroid thickness.
GCC and INL thickness reduced in the outer retinal regions.
Significant correlations were found between AL and cone density/spacing.
Despite reduced cone density, best-corrected visual acuity (BCVA) remained 20/20 or greater.

Conclusions:

Myopic eyes exhibit thinning of the lens, ORL, and reduced cone density.
Axial elongation is linked to decreased ORL thickness and cone density.
Lens thinning may indicate intrinsic accommodation changes.
These findings contribute to a deeper understanding of myopia's morphological alterations.