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Exocrine pancreatic function in dyspepsia.

H Worning

    Digestion
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Chronic pancreatitis incidence varies widely due to diagnostic challenges. Enzyme replacement therapy is needed for exocrine pancreatic insufficiency in several conditions.

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    Area of Science:

    • Gastroenterology
    • Epidemiology

    Background:

    • Dyspepsia prevalence attributed to pancreatic diseases varies significantly (0-30%).
    • Chronic pancreatitis incidence rates are unsettled, ranging from 0.7 to 10 per 100,000 person-years.
    • Variability stems from differing clinical awareness and diagnostic practices for pancreatic studies in dyspepsia patients.

    Purpose of the Study:

    • To review the epidemiology of chronic pancreatitis and related pancreatic diseases.
    • To estimate the prevalence of exocrine pancreatic insufficiency and the demand for enzyme substitution.
    • To discuss the association between pancreatic function, diseases, and gastrointestinal conditions.

    Main Methods:

    • Literature review and analysis of existing epidemiological data.
    • Calculation of prevalence and incidence rates based on available studies.

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  • Discussion of the relationship between pancreatic diseases and other gastrointestinal disorders.

    • Main Results:

    • Estimated prevalence of chronic pancreatitis in the Western world is approximately 70 per 100,000 inhabitants.
    • About one-third of chronic pancreatitis patients exhibit exocrine pancreatic insufficiency.
    • Demand for enzyme substitution is estimated at 150 patients per million inhabitants for chronic pancreatitis, pancreatic cancer, and cystic fibrosis.

    Conclusions:

    • The epidemiology of chronic pancreatitis remains incompletely defined, influenced by diagnostic inconsistencies.
    • Exocrine pancreatic insufficiency is a significant complication of chronic pancreatitis, necessitating enzyme replacement.
    • The potential analgesic effect of pancreatic enzyme substitution requires further investigation.